All posts by wohlwila
Week 12 Reading
Go to the following site and go through the animation and the problems
Genetic Code and Protein Synthesis Animation
Answer these questions for review
https://goo.gl/forms/Ns6mxalC88mkBCKL2
Fakebook
Post the URL to your fakebook site so that others can view it. Post in the Comment section below.
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Welcome to My blog Sites. This is your first post. Edit or delete it, then start blogging!
Article Posting
- Find an article that has to do with some aspect of Biotechnolgy
- Give a short description describing what was accomplished and how they did it. Use your own words!
- Put the URL and your description under the comments here
Test
The elucidation of the structure of the double helix provided a hint as to how DNA divides and makes copies of itself. This model suggests that the two strands of the double helix separate during replication, and each strand serves as a template from which the new complementary strand is copied. What was not clear was how the replication took place. There were three models suggested (Figure): conservative, semi-conservative, and dispersive.
In conservative replication, the parental DNA remains together, and the newly formed daughter strands are together. The semi-conservative method suggests that each of the two parental DNA strands act as a template for new DNA to be synthesized; after replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. In the dispersive model, both copies of DNA have double-stranded segments of parental DNA and newly synthesized DNA interspersed.
Meselson and Stahl were interested in understanding how DNA replicates. They grew E. coli for several generations in a medium containing a “heavy” isotope of nitrogen (15N) that gets incorporated into nitrogenous bases, and eventually into the DNA (Figure).
Gender Determination Exercise
Go to http://www.hhmi.org/biointeractive/gender-testing-athletes
Go through the activities in this site and answer the following questions (some of them are in the site itself)
- Can a test determine an individual’s biological sex? And can testosterone produced by an athlete’s own body provide an unfair advantage?
- At the bottom of the section on development is a graph showing testosterone levels for male and female athletes. Most female athletes have less than 5 nm/L of testosterone, but a few have as high as 30 nmol/L which is above the average for male athletes. Which genetic condition(s) can cause XX individuals to have high testosterone levels?
(3) The AR gene codes for a transcription factor which is only functional when testosterone is present. Based on what you know about transcription factors and about sex determination explain
(A) Why do XY individuals with a mutation in the AR gene develop as females despite having male levels of testosterone?
(B) Would you expect such individuals to be more muscular than an average female?
(4) Do the case studies for the sprinter and the swimmer. Should they be eligible to compete? Explain your answer.
Genetics Projects
Post the URL of the project you made here. Post it as a comment on this blog.
Musuclar Dystrophy and Medical Ethics
Read the following:
Then answer the following questions:
Would you expect the 2 daughters of the mother in the article to have a chance to have sons with muscular dystrophy? Explain.
Should we as a society spend more or less on diseases like Duchenne muscular dystrophy? Note that Duchenne Muscular dystrophy is fairly common compared to most single gene diseases, but much rarer than conditions like heart disease or autism.
If a cure is found but it is very expensive, should it be available to everybody? Why or why not?
A doctor in that article made (what I believe) to be a serious ethical error. What was it? Discuss.
Write your answers as a reply in the comments section
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